The University of Michigan Medical School

Human Genetics Department

©2018 by Chromatin Neurobiology Lab. 

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Selected Publications

Front Mol Neurosci 11:104

April 04, 2018

Christina's first first-author research article. We describe a patient mutation in KDM5C which has altered gene regulatory function in neurons.

Mol Cell Neurosci 87:35-45

December 25, 2017

Review article by Bobby & Farris on alternative splicing in the brain.

Neuroscience 370:170-180

May 29, 2017

Bobby's first first-author research paper published.

Epigenomics 8(12):1689-1708

November 14, 2016

Tricia's first first-author paper published

Cell Rep. 14(5):1000-9.

February 09, 2016

Characterization of Kdm5c-Knockout mice. These mice will be valuable for future therapeutic development of intellectual disability and autism spectrum disorders. 

Epigenomics. 7(3):503-19. Review Article.

March 01, 2015

Christina's first first-author paper. We summarized neuroveleopmental disorders associated with mutations in regulators of the most-extensively controlled histone modification, H3K4me. 

Nat Commun. ;6:6002. doi: 10.1038/ncomms7002.

January 22, 2015

The first paper from the lab! We developped a new RNA-seq method which allows us to profile full-length transcripts. 

Nat Struct Mol Biol. 18(7):769-76. doi: 10.1038/nsmb.2062.

June 22, 2011

We found that ADD domain of ATRX, which is enriched with ATRX-syndrome mutations, is a reading module for heterochromatin histone methylation status, low H3K4me and hight H3K9me3.

Cell. 128(6):1077-88. Epub 2007 Feb 22.

February 22, 2007

We discovered the first family of enzymes which can remove H3K4me3. One of the family members, JARID1C/KDM5C was known to be mutated in X-linked intellectual disability. We linked hitone methylation dynamics and human cognitive development for the first time. 

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