We found mutually suppressive roles of H3K4me writer KMT2A and eraser KDM5C. This work provides proof of principle of modulating single methyl histone enzymes to ameliorate neurodevelopmental disorders.
Front Mol Neurosci 11:104
April 04, 2018
Christina's first first-author research article. We describe a patient mutation in KDM5C which has altered gene regulatory function in neurons.
Mol Cell Neurosci 87:35-45
December 25, 2017
Review article by Bobby & Farris on alternative splicing in the brain.
May 29, 2017
Bobby's first first-author research paper published.
November 14, 2016
Tricia's first first-author paper published
Cell Rep. 14(5):1000-9.
February 09, 2016
Characterization of Kdm5c-Knockout mice. These mice will be valuable for future therapeutic development of intellectual disability and autism spectrum disorders.
Epigenomics. 7(3):503-19. Review Article.
March 01, 2015
Christina's first first-author paper. We summarized neuroveleopmental disorders associated with mutations in regulators of the most-extensively controlled histone modification, H3K4me.
Nat Commun. ;6:6002. doi: 10.1038/ncomms7002.
January 22, 2015
The first paper from the lab! We developped a new RNA-seq method which allows us to profile full-length transcripts.
We found that ADD domain of ATRX, which is enriched with ATRX-syndrome mutations, is a reading module for heterochromatin histone methylation status, low H3K4me and hight H3K9me3.
Cell. 128(6):1077-88. Epub 2007 Feb 22.
February 22, 2007
We discovered the first family of enzymes which can remove H3K4me3. One of the family members, JARID1C/KDM5C was known to be mutated in X-linked intellectual disability. We linked hitone methylation dynamics and human cognitive development for the first time.