We found that ADD domain of ATRX, which is enriched with ATRX-syndrome mutations, is a reading module for heterochromatin histone methylation status, low H3K4me and hight H3K9me3.
Cell. 128(6):1077-88. Epub 2007 Feb 22.
February 22, 2007
We discovered the first family of enzymes which can remove H3K4me3. One of the family members, JARID1C/KDM5C was known to be mutated in X-linked intellectual disability. We linked hitone methylation dynamics and human cognitive development for the first time.