The University of Michigan Medical School
Human Genetics Department
Ann Arbor, MI, 48108
Email: siwase@umich.edu
Phone: +1-734-647-8832
Connect with us
OUR LABORATORY
Histone modification dynamics in the brain
Our primary research goal is to understand how the dynamic regulation of chromatin, the DNA-containing macromolecule, engages in brain development and function. The results of our studies will likely provide an important foundation for future treatments of cognitive disorders, such as intellectual disabilities and autism spectrum disorders. We are located within the Dept. of Human Genetics at the University of Michigan, Ann Arbor.
LAB NEWS
NEW PAPER!
New paper published
We found unique roles for the six histone H3K4 methylation writers in regulating distinct facets of homeostatic synaptic scaling. Among the six enzymes, KMT2A is key for the induction of synaptic downscaling by installing H3K4me1 early after network hyperactivity to elicit transcriptional responses necessary for synaptic adaptations.
Community impact
Our lab
We're proud to support the efforts of the patient foundations and groups for the genes we study.
We are a diverse group of scientists passionate about chromatin dynamics in the developing brain!
