The University of Michigan Medical School
Human Genetics Department
Ann Arbor, MI, 48108
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Uncover Histone-based Mechanisms underlying Neurodevelopmental Disorders
Unlike the synapses, the nucleus is a less well studied compartment within neurons. Within the nucleus, the heritable information, the DNA, is wrapped around four small proteins known as “histones” (H2A, H2B, H3, and H4). Recent advances in human genetics have made it increasingly clear that these histones can be a major cause of intellectual disabilities (IDs) and Autism Spectrum Disorders (ASDs) if their regulatory mechanisms are disrupted by genetic mutations. However, it is largely unknown how such mutations can lead to abnormal brain development and function. A principal aim of our research is to elucidate the histone-related mechanisms underlying IDs and ASDs.