The University of Michigan Medical School
Human Genetics Department
Ann Arbor, MI, 48108
Email: siwase@umich.edu
Phone: +1-734-647-8832
Connect with us
OUR LABORATORY
Histone modification dynamics in the brain
Our primary research goal is to understand how the dynamic regulation of chromatin, the DNA-containing macromolecule, engages in brain development and function. The results of our studies will likely provide an important foundation for future treatments of cognitive disorders, such as intellectual disabilities and autism spectrum disorders. We are located within the Dept. of Human Genetics at the University of Michigan, Ann Arbor.
LAB NEWS
NEW PAPER!
New paper published
Some models of neurodevelopmental disorders surprisingly show ectopic expression of germline genes in the brain. In this perspective article, we explore this soma-to-germline transformation could lead to a severe identity crisis of brain cells—potentially interfering with normal brain development.
KDM5C Registry
KDM5C Foundation
The KDM5C Registry's purpose is to gather demographic and clinical information on KDM5C patients in both a centralized location and standard format. It was created to serve the parent, patient, physician, and research communities as we strive for a better understanding of KDM5C on the path to finding treatments.
Several KDM5C families came together with the idea of creating Foundation to improve the lives of KDM5C-affected families. The KARES foundation was formed in 2022, a nonprofit 501(C)(3) dedicated KDM5C advocacy, research, education, & support for individuals and families living with KDM5C syndrome around the globe.
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