The University of Michigan Medical School
Human Genetics Department
Ann Arbor, MI, 48108
Email: siwase@umich.edu
Phone: +1-734-647-8832
Connect with us
OUR LABORATORY
Histone modification dynamics in the brain
Our primary research goal is to understand how the dynamic regulation of chromatin, the DNA-containing macromolecule, engages in brain development and function. The results of our studies will likely provide an important foundation for future treatments of cognitive disorders, such as intellectual disabilities and autism spectrum disorders. We are located within the Dept. of Human Genetics at the University of Michigan, Ann Arbor.
LAB NEWS
NEW PAPER!
New paper published
We uncovered neuron-specific splicing events for 14 chromatin regulators, including H3K4 demethylase LSD1 and reader PHF21A. We show how ubiquitously expressed chromatin regulatory complexes can exert neuron-specific functions via alternative splicing of their subunits.
Community impact
Our lab
We're proud to support the efforts of the patient foundations and groups for the genes we study.
We are a diverse group of scientists passionate about chromatin dynamics in the developing brain!
