top of page

Histone modification dynamics in the brain

Our primary research goal is to understand how the dynamic regulation of chromatin, the DNA-containing macromolecule, engages in brain development and function. The results of our studies will likely provide an important foundation for future treatments of cognitive disorders, such as intellectual disabilities and autism spectrum disorders. We are located within the Dept. of Human Genetics at the University of Michigan, Ann Arbor.


New paper published

Some models of neurodevelopmental disorders surprisingly show ectopic expression of germline genes in the brain. In this perspective article, we explore this soma-to-germline transformation could lead to a severe identity crisis of brain cells—potentially interfering with normal brain development. 

KDM5C Registry

KDM5C Foundation

The KDM5C Registry's purpose is to gather demographic and clinical information on KDM5C patients in both a centralized location and standard format. It was created to serve the parent, patient, physician, and research communities as we strive for a better understanding of KDM5C on the path to finding treatments.

Several KDM5C families came together with the idea of creating Foundation to improve the lives of KDM5C-affected families. The KARES foundation was formed in 2022, a nonprofit 501(C)(3) dedicated KDM5C advocacy, research, education, & support for individuals and families living with KDM5C syndrome around the globe.

The Core Question

A central question underpinning our research is how the chemical language embedded in chromatin engages in brain development and function.

bottom of page