Histone modification dynamics in the brain
Our primary research goal is to understand how the dynamic regulation of chromatin, the DNA-containing macromolecule, engages in brain development and function. The results of our studies will likely provide an important foundation for future treatments of cognitive disorders, such as intellectual disabilities and autism spectrum disorders. We are located within the Dept. of Human Genetics at the University of Michigan, Ann Arbor.
New paper published
Some models of neurodevelopmental disorders surprisingly show ectopic expression of germline genes in the brain. In this perspective article, we explore this soma-to-germline transformation could lead to a severe identity crisis of brain cells—potentially interfering with normal brain development.