Histone modification dynamics in the brain

Our primary research goal is to understand how the dynamic regulation of chromatin, the DNA-containing macromolecule, engages in brain development and function. The results of our studies will likely provide an important foundation for future treatments of cognitive disorders, such as intellectual disabilities and autism spectrum disorders. We are located within the Dept. of Human Genetics at the University of Michigan, Ann Arbor.


Postdoc wanted!

The Iwase & Seo laboratories at the University of Michigan are seeking a jointly-appointed postdoctoral fellow to investigate how metals, such as iron and manganese, work with chromatin to ensure normal brain development and function using biochemistry, mouse, and cell culture models.

New research paper published

We found the roles of RAI1, Smith-Magnis Syndrome gene, in neuronal activity-dependent transcription, and synaptic scaling.  This work also highlights the utility of nascent RNA sequencing to probe the roles of chromatin regulators in neural ensembles. 

The Core Question

A central question underpinning our research is how the chemical language embedded in chromatin engages in brain development and function.

The University of Michigan Medical School

Human Genetics Department

©2018 by Chromatin Neurobiology Lab. 

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