Histone modification dynamics in the brain

Our primary research goal is to understand how the dynamic regulation of chromatin, the DNA-containing macromolecule, engages in brain development and function. The results of our studies will likely provide an important foundation for future treatments of cognitive disorders, such as intellectual disabilities and autism spectrum disorders. We are located within the Dept. of Human Genetics at the University of Michigan, Ann Arbor.


New research paper published

We found the roles of RAI1, Smith-Magnis Syndrome gene, in neuronal activity-dependent transcription, and synaptic scaling.  This work also highlights the utility of nascent RNA sequencing to probe the roles of chromatin regulators in neural ensembles. 

KDM5C Registry

The KDM5C Registry's purpose is to gather demographic and clinical information on KDM5C patients in both a centralized location and standard format. It was created to serve the parent, patient, physician, and research communities as we strive for a better understanding of KDM5C on the path to finding treatments.

The Core Question

A central question underpinning our research is how the chemical language embedded in chromatin engages in brain development and function.