Histone modification dynamics in the brain
Our primary research goal is to understand how the dynamic regulation of chromatin, the DNA-containing macromolecule, engages in brain development and function. The results of our studies will likely provide an important foundation for future treatments of cognitive disorders, such as intellectual disabilities and autism spectrum disorders. We are located within the Dept. of Human Genetics at the University of Michigan, Ann Arbor.
New research paper published
The article describes Christina's thesis work. We found that KDM5C and KMT2A are suppressors of each other in neurodevelopment. This work provides a proof of principle of modulating single methyl histone writer and eraser enzymes to ameliorate neurodevelopmental disorders.