Out this month is our latest paper showing KDM1A (aka LSD1) maintains optimal enhancer activity by counterbalancing H3K4 methylation at enhancers. This project was lead by former postdoc Dr. Saurabh Agarwal, and current PhD candidate Katie Bonefas.
We found that loss of Kdm1a in mouse neurons lead to premature activation of neuronal activity-dependent enhancers & genes. A basic research step towards understanding the associated human KDM1A / LSD1 neurodevelopmental syndrome.
Read the study here: